ENTRY D0562 20190821 D121D056200000001 SUBENT D0562001 20190821 D121D056200100001 BIB 13 59 D056200100002 TITLE Production of 230U/226Th for Targeted Alpha Therapy D056200100003 via Proton Irradiation of 231Pa D056200100004 AUTHOR (A.Morgenstern,O.Lebeda,J.Stursa,F.Bruchertseifer, D056200100005 R.Capote,J.McGinley,G.Rasmussen,M.Sin,B.Zielinska, D056200100006 C.Apostolidis) D056200100007 INSTITUTE (2ZZZITU,3CZRUJF,3ZZZIAE,3RUMBUU) D056200100008 REFERENCE (J,AC,80,8763,2008) D056200100009 REL-REF (R,,R.B.Firestone+,B,FIRESTONE,,,1998) Decay constantsD056200100010 DECAY-DATA Decay data were taken from Website of: D056200100011 Nucleonica: Web driven nuclear science. European D056200100012 Commission, Joint Research Centre, Institute for D056200100013 Transuranium Elements,2007 D056200100014 http://www.nucleonica.net/index.aspx D056200100015 and from R.B.Firestone,S.Y.F.Chu,C.M.Baglin, Update to D056200100016 the 8th Edition of the Table of Isotopes: D056200100017 John Wiley & Sons Inc.: New York, 1998 D056200100018 FACILITY (ISOCY,3CZRUJF) The isochronous cyclotron U-120 M of D056200100019 the Nuclear Physics Institute in Rez, Czech Republic D056200100020 METHOD (GSPEC,ACTIV) D056200100021 MONITOR Copper foils of 10.6-mu-m thickness (99.99%,Goodfellow)D056200100022 were used as monitor foils and irradiated immediately D056200100023 before irradiation of protactinium targets in D056200100024 identical positions using identical beam parameters. D056200100025 IAEA Charged-Particle Cross Section Database for D056200100026 Medical Radioisotope Production, updated March 2007; D056200100027 http://www-nds.iaea.org/medical/monitor reactions.html.D056200100028 (29-CU-0(P,X)30-ZN-62,,SIG) D056200100029 (29-CU-0(P,X)30-ZN-63,,SIG) D056200100030 (29-CU-0(P,X)30-ZN-65,,SIG) D056200100031 DETECTOR (HPGE) High-resolution gamma-spectrometry (HRGS) of D056200100032 activated monitor foils was performed using a D056200100033 gamma-spectrometer equipped with a HPGe detector D056200100034 (GMX45-Plus, FWHM 2.04 at 1332.5 keV, amplifier 671, D056200100035 ADC TRUMP-8K-IN LINE, multichannel analyzer D056200100036 TRUMP-8K, software Maestro for Windows; Ortec). The D056200100037 spectrometer was calibrated for absolute counting D056200100038 efficiency with a set of gamma-ray standards (152Eu, D056200100039 137Cs, 60Co, 133Ba, and 241Am, uncertainty of the D056200100040 activities <1%, Czech Institute for Metrology, D056200100041 Department of Ioniz. Radia-n) for various geometries. D056200100042 ERR-ANALYS The overall uncertainty in the determination of D056200100043 the 230U cross sections was <16%. D056200100044 There are several major contributions to the overall D056200100045 uncertainty of the determined cross sections: D056200100046 (ERR-1) uncertainty in normalization; D056200100047 (ERR-2) uncertainty in the thickness of the D056200100048 monitoring foil; D056200100049 (ERR-3) uncertainty in the determination of the D056200100050 activity of 230U, 62Zn, 63Zn, and 65Zn, D056200100051 including the uncertainty of their decay data D056200100052 (ERR-4) uncertainty in the thickness of the D056200100053 irradiated 231Pa layer and D056200100054 (ERR-5) uncertainty in the determination of 230U D056200100055 activity . D056200100056 STATUS (APRVD) Entry approved by Dr. A.Morgenstern D056200100057 HISTORY (20090217C) D056200100058 (20190821A) SD: REACTION code updated according to new D056200100059 EXFOR rules in Subent 003. D056200100060 On. Definition of ERR-T moved to 002. D056200100061 ENDBIB 59 0 D056200100062 COMMON 5 3 D056200100063 ERR-1 ERR-2 ERR-3 ERR-4 ERR-5 D056200100064 PER-CENT PER-CENT PER-CENT PER-CENT PER-CENT D056200100065 10.0 2.0 5.0 10.0 5.0 D056200100066 ENDCOMMON 3 0 D056200100067 ENDSUBENT 66 0 D056200199999 SUBENT D0562002 20190821 D121D056200200001 BIB 5 17 D056200200002 REACTION (91-PA-231(P,2N)92-U-230,,SIG) D056200200003 SAMPLE Thin targets of 231Pa were prepared by D056200200004 electrodeposition on silver disks (99.99%, Alfa D056200200005 Aesar) of 0.25-mm thickness and 20- mm diameter used D056200200006 as cathode. Aliquots of 231Pa in 0.4 M ammonium D056200200007 oxalate were added to the electrolysis cell D056200200008 containing 8.9 mL of 4% ammonium chloride/4% D056200200009 ammonium oxalate solution and 10 mu-L of D056200200010 concentrated hydrofluoric acid. D056200200011 Targets were contained 10.4-19.1 mu-g of 231Pa. D056200200012 Subsequently the silver disks were covered with D056200200013 aluminum foils (34.9-mu-m thick., 99.99%, Alfa Aesar) D056200200014 acting as catcher foils to avoid any losses of D056200200015 activity by recoil processes. D056200200016 ERR-ANALYS (ERR-T) Total uncertainty D056200200017 STATUS (TABLE) Table 1 of Anal.Chem.80(2008)8763 D056200200018 HISTORY (20190821A) On. Definition of ERR-T moved from 001. D056200200019 ENDBIB 17 0 D056200200020 COMMON 1 3 D056200200021 EN-ERR D056200200022 MEV D056200200023 0.2 D056200200024 ENDCOMMON 3 0 D056200200025 DATA 3 20 D056200200026 EN DATA ERR-T D056200200027 MEV MB MB D056200200028 10.6 2.6 0.4 D056200200029 10.6 2.8 0.5 D056200200030 11.5 5.0 0.8 D056200200031 11.8 12.8 2.0 D056200200032 12.5 13.9 2.2 D056200200033 12.8 19.0 3.0 D056200200034 13.5 23.6 3.8 D056200200035 13.6 31.9 5.1 D056200200036 14.6 33.2 5.3 D056200200037 14.7 27.0 4.3 D056200200038 15.5 26.4 4.2 D056200200039 15.5 23.1 3.7 D056200200040 16.6 21.8 3.5 D056200200041 16.7 16.6 2.7 D056200200042 16.8 15.7 2.5 D056200200043 17.2 12.8 2.1 D056200200044 17.9 12.9 2.1 D056200200045 21.0 7.8 1.2 D056200200046 22.6 7.6 1.2 D056200200047 23.8 7.4 1.2 D056200200048 ENDDATA 22 0 D056200200049 ENDSUBENT 48 0 D056200299999 SUBENT D0562003 20190821 D121D056200300001 BIB 5 18 D056200300002 REACTION (91-PA-OXI(P,X)92-U-230,,TTY,,(PHY)) D056200300003 SAMPLE Thick targets for production runs were prepared from D056200300004 protactinium pentoxide. The resulting oxide was D056200300005 ground in a mortar together with 2 mg of zinc D056200300006 stearate and aliquots of 235 mg of protactinium D056200300007 pentoxide, corresponding to 200 mg of 231Pa, were D056200300008 pressed into circular pellets with a diameter of 6 D056200300009 mm at a pressure of 5 tons/cm2. D056200300010 The final pellets had a diameter of 4.9 mm and a D056200300011 thickness of 1.3-1.4 mm. Subsequently, the pellets D056200300012 were enclosed in silver capsules made from silver D056200300013 disks (30-mm diameter, 0.25-mm thickness), which were D056200300014 welded gastight. D056200300015 COMMENT From N.Otsuka: 'Oxide target was used. Not clear if D056200300016 the given yield value was corrected for the target ' D056200300017 STATUS (TABLE) Table 2 of Anal.Chem.80(2008)8763 D056200300018 HISTORY (20190821A) SD: SF1=Pa-231 -> Pa-OXI; SF3=2N -> X; D056200300019 SF8=DT -> (PHY) in REACTION code. COMMENT added. D056200300020 ENDBIB 18 0 D056200300021 COMMON 1 3 D056200300022 EN-ERR D056200300023 MEV D056200300024 0.2 D056200300025 ENDCOMMON 3 0 D056200300026 DATA 3 1 D056200300027 EN-MIN EN-MAX DATA D056200300028 MEV MEV MBQ/MUAHR D056200300029 10.5 24.0 0.245 D056200300030 ENDDATA 3 0 D056200300031 ENDSUBENT 30 0 D056200399999 ENDENTRY 3 0 D056299999999